Melting Point Certified Reference Standards
Application Note #2
What is a Certified Reference Standard?
Certified Reference Standards (CRSs) are high-purity chemicals certified by
national, local or international standards laboratories and pharmacopeias, which
are produced and tested according to well established and easy-to-reproduce
Use CRSs for temperature scale calibration and determination of acceptability of
melting point (MP) instruments including OptiMelt.
General Guidelines and Recommendations
Use CRSs obtained from reputable standards and pharmacopeia
Use CRSs with certificates of measurement including records of:
(1) Lot/batch Identification number (for traceability)
(2) Purity specification (analysis method, purity levels, etc.)
(3) Detailed description of the instrumental setup used for the melting
point determination (i.e. type of instrument, manual or automatic
detection, hot bat|